Article

Dimerization of ADAR1 modulates site-specificity of RNA editing

2023-12-05

Abstract excerpt

Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA (ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in mammals, ADAR1 is responsible for the vast majority of the editing events and acts on thousands of sites in the human transcriptome. ADAR1 has been proposed to form a stable homodimer and dimerization is suggested to be important for editing activity. In the...

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Literature Corpus work: e91c17b9-b773-5b63-bb5e-404f6e5c80a8
DOI: 10.1101/2023.12.05.570066

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