Structural Impacts of Two Disease-linked ADAR1 Mutants: A Molecular Dynamics Study

Abstract excerpt

<title>Abstract</title> <p>Adenosine deaminases acting on RNA (ADARs) are pivotal RNA-editing enzymes responsible for converting adenosine to inosine within double-stranded RNA (dsRNA). Dysregulation of ADAR1 editing activity, often arising from genetic mutations, has been linked to elevated interferon levels and the onset of autoinflammatory diseases. However, understanding the molecular underpinnings of this dy...

Topics

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• Adenosine Deaminase
• Molecular Dynamics Simulation
• Mutation
• Protein Conformation
• RNA-Binding Proteins
• RNA, Double-Stranded
• RNA Editing
• RNA regulation and disease

Identifiers and source

Literature Corpus work

e4868004-f8ec-508a-bfb8-f1f81aa8bcce

DOI

10.21203/rs.3.rs-4356501/v1