Article
High-throughput mutagenesis reveals unique structural features of human ADAR1.
Nature communications - 12 Oct 2020
Park SeHee, Doherty Erin E, Xie Yixuan, Padyana Anil K, Fang Fang, Zhang Yue, Karki Agya, Lebrilla Carlito B, Siegel Justin B, Beal Peter A
Abstract excerpt
Adenosine Deaminases that act on RNA (ADARs) are enzymes that catalyze adenosine to inosine conversion in dsRNA, a common form of RNA editing. Mutations in the human ADAR1 gene are known to cause disease and recent studies have identified ADAR1 as a potential therapeutic target for a subset of cancers. However, efforts to define the mechanistic effects for disease associated ADAR1 mutations and the rational...
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