Article
A protein-protein interaction underlies the molecular basis for substrate recognition by an adenosine-to-inosine RNA-editing enzyme.
Nucleic acids research - 12 Oct 2018
Rajendren Suba, Manning Aidan C, Al-Awadi Haider, Yamada Kentaro, Takagi Yuichiro, Hundley Heather A
Abstract excerpt
Adenosine deaminases that act on RNA (ADARs) convert adenosine to inosine within double-stranded regions of RNA, resulting in increased transcriptomic diversity, as well as protection of cellular double-stranded RNA (dsRNA) from silencing and improper immune activation. The presence of dsRNA-binding domains (dsRBDs) in all ADARs suggests these domains are important for substrate recognition; however, the role of...
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