Biochemical profiling and structural basis of ADAR1-mediated RNA editing.

doi:10.1016/j.molcel.2025.02.017

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Article

Biochemical profiling and structural basis of ADAR1-mediated RNA editing.

Molecular cell - 3 Apr 2025

Deng Xiangyu, Sun Lina, Zhang Min, Basavaraj Rashmi, Wang Jin, Weng Yi-Lan, Gao Yang

Abstract excerpt

ADAR1 regulates RNA-induced immune responses by converting adenosine to inosine in double-stranded RNA. Mutations in ADAR1 are associated with human autoimmune disease, and targeting ADAR1 has been proposed for cancer immunotherapy. However, the molecular mechanisms underlying ADAR1-mediated editing remain unclear. Here, we provide detailed biochemical and structural characterizations of human ADAR1. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40101712
DOI: 10.1016/j.molcel.2025.02.017
PMCID: PMC11972152

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