Article
Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Nucleic acids research - 20 Aug 2020
Thuy-Boun Alexander S, Thomas Justin M, Grajo Herra L, Palumbo Cody M, Park SeHee, Nguyen Luan T, Fisher Andrew J, Beal Peter A
Abstract excerpt
Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosine to inosine in duplex RNA, a modification that exhibits a multitude of effects on RNA structure and function. Recent studies have identified ADAR1 as a potential cancer therapeutic target. ADARs are also important in the development of directed RNA editing therapeutics. A comprehensive understanding of the molecular mechanism of the ADAR...
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