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Article

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.

Science (New York, N.Y.) - 4 Sept 2015

Liddicoat Brian J, Piskol Robert, Chalk Alistair M, Ramaswami Gokul, Higuchi Miyoko, Hartner Jochen C, Li Jin Billy, Seeburg Peter H, Walkley Carl R

Abstract excerpt

Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to RNA editing, additional functions have been proposed for ADAR1. To determine the specific role of RNA editing by ADAR1, we generated mice with an editing-deficient knock-in mutation (Adar1(E861A), where E861A denotes Glu(861)→Ala(861))....

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Share to Adenosine
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo Loss

Share to Gene Knock-In Techniques

Share to Inosine

Share to Interferon-Induced Helicase, IFIH1

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Source

Open in PubMed Open full text

Identifiers

PMID: 26275108
DOI: 10.1126/science.aac7049
PMCID: PMC5444807

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.PMID 26275108Read ↗

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Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human DiseasesSemantic proximity Read ↗

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNASemantic proximity Read ↗

Adenosine-to-Inosine (A-to-I) RNA Editing by ADAR1 to Control RNA Sensing in Cardiovascular Disease.Semantic proximity Read ↗

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogenesesSemantic proximity Read ↗

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.Semantic proximity Read ↗

Adenosine Deaminases Acting on RNA (ADARs) and Viral InfectionsSemantic proximity Read ↗

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.Semantic proximity Read ↗

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Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisSemantic proximity Read ↗

RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicingSemantic proximity Read ↗

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