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Article

Mechanistic insights into editing-site specificity of ADARs.

Proceedings of the National Academy of Sciences of the United States of America - 27 Nov 2012

Kuttan Ashani, Bass Brenda L

Abstract excerpt

Adenosine deaminases that act on RNA (ADARs) deaminate adenosines in dsRNA to produce inosines. ADARs are essential in mammals and are particularly important in the nervous system. Altered levels of adenosine-to-inosine (A-to-I) editing are observed in several diseases. The extent to which an adenosine is edited depends on sequence context. Human ADAR2 (hADAR2) has 5' and 3' neighbor preferences, but which amino...

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Share to Adenosine Deaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23129636
DOI: 10.1073/pnas.1212548109
PMCID: PMC3511710

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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