Article

TOGGLE Unveils Functional Heterogeneity and Epigenetic Memory in Single Cells

2025-01-02

Abstract excerpt

Cells that appear transcriptionally identical can maintain vastly different functions or fates—an enduring blind spot in single-cell transcriptomics. Here we introduce TOGGLE, a self-supervised graph diffusion framework that delineates fine-grained functional heterogeneity within phenotypically stable cell populations. By combining deep diffusion learning with reinforcement-guided clustering and a BERT-inspired ma...

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Literature Corpus work: 77755de3-8cd6-5e5a-a616-71d777b0072c
DOI: 10.1101/2025.01.01.631041

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