Article
Methods and sensors for functional genomic studies of cell-cycle transitions in single cells.
Physiological genomics - 1 Oct 2020
Zambon Alexander C, Hsu Tom, Kim Seunghee Erin, Klinck Miranda, Stowe Jennifer, Henderson Lindsay M, Singer Donald, Patam Leomar, Lim Curtis, McCulloch Andrew D, Hu Bing, Hickerson Anna I
Abstract excerpt
Much of our understanding of the regulatory mechanisms governing the cell cycle in mammals has relied heavily on methods that measure the aggregate state of a population of cells. While instrumental in shaping our current understanding of cell proliferation, these approaches mask the genetic signatures of rare subpopulations such as quiescent (G0) and very slowly dividing (SD) cells. Results described in this...
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