Article

Feedback regulation between FOXM1 and APC/C <sup>Cdh1</sup> determines the changes in cell cycle dynamics during aging

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Aging is characterised by a loss of regenerative capacity, though it remains elusive how aged proliferating cells slowdown cycling eventually becoming senescent. We previously found that repression of the FOXM1 transcription factor accounts for mitotic decline during aging due to a global transcriptional shutdown of mitotic genes in proliferating cells. Intriguingly, a 1.5-fold increase in both...

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Literature Corpus work: c1358160-ae86-5a94-b062-e0e482ad7358
DOI: 10.1101/2025.01.26.634919

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