Article

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

2021-05-05

Abstract excerpt

<title>Abstract</title> <p>Unsupervised clustering and deconvolution analysis identifies a novel subtype of M-CRPC endowed with hybrid epithelial/mesenchymal (E/M) and luminal progenitor-like traits (Mesenchymal and Stem-like PC, MSPC). Analysis of patient datasets and mechanistic studies indicate that MSPC arises as a consequence of therapy-induced lineage plasticity. AR blockade instigates two separate and comp...

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Literature Corpus work: e914113b-2411-5d7a-b1d6-f9c06afd8ef5
DOI: 10.21203/rs.3.rs-444925/v1

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