Article

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

2021-11-01

Abstract excerpt

The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this lineage plasticity in a primary murine prostate organoid model that mirrors the lineage transition seen in patients. These cells lose luminal identity within weeks fol...

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Literature Corpus work: 2f4bc774-68a9-56fc-b8cc-cc94d76bd86a
DOI: 10.1101/2021.11.01.466615

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