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Phenotypic Plasticity - Alternate Transcriptional Programs Driving Treatment Resistant Prostate Cancer

1 Jan 2022

Abstract excerpt

Androgen deprivation therapy (ADT) that antagonizes androgen receptor (AR) signaling has made significant increases to overall survival of prostate cancer patients. However, ADT is not curative, and patients eventually progress to castration resistant disease (CRPC). It has become evident that a subset of prostate cancers acquire ADT resistance through mechanisms independent of AR alteration or reprogramming of...

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PMID: 35993978
DOI: 10.1615/critrevoncog.2022043096

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