Article

A genetic switch involving EGR1 and EZH2 links aging and development across human tissues

2026-07-30

Abstract excerpt

Aging is often regarded as the last chapter of development. There is growing evidence that aging and development are mechanistically linked. Here we describe a genetic switch involving EZH2 and EGR1 as opposing regulatory nodes that appears to connect aging and development across human tissues. We show that this switch defines two distinct states in fibroblasts: a proliferative (EZH2-high/EGR1-low) state and a non...

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Identifiers and source

Literature Corpus work: e913de73-8c67-5d75-bbe3-68539f4d491b
DOI: 10.64898/2026.07.29.741427

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