Article

<i>MECP2</i> Mutations Rewire Human ESC Fate and Bias Cortical Lineage Commitment

2025-10-02

Abstract excerpt

<h4>Summary</h4> Rett syndrome arises from loss-of-function mutations in the X-linked chromatin regulator MECP2 , yet the earliest molecular derailments in human development remain poorly defined. Using isogenic hESC models carrying three patient-derived MECP2 mutations, we followed the transcriptome from pluripotency through neuro-ectoderm, neural stem, and neural progenitor stages and into three-month cerebra...

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Literature Corpus work: 0c987e19-61ab-5682-a8fb-e5759b7895d4
DOI: 10.1101/2025.09.30.679576

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