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Adult Stem Cells and Diseases of Aging

21 Jan 2014

Abstract excerpt

Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling, premature senescence as a response to oncogenic insults to the somatic genome, and other causes contribute to tissue degeneration with age. Both progeria, an extreme example of early-onset aging, and heritable longevity have provided...

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PMID: 24757526
DOI: 10.3390/jcm3010088

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