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Article

Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes.

Cell death & disease - 16 Sept 2021

El Said Nadine Hosny, Della Valle Francesco, Liu Peng, Paytuví-Gallart Andreu, Adroub Sabir, Gimenez Juliette, Orlando Valerio

Abstract excerpt

PRC2-mediated epigenetic function involves the interaction with long non-coding RNAs (lncRNAs). Although the identity of some of these RNAs has been elucidated in the context of developmental programs, their counterparts in postmitotic adult tissue homeostasis remain uncharacterized. To this aim, we used terminally differentiated postmitotic skeletal muscle cells in which oxidative stress induces the dynamic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34531374
DOI: 10.1038/s41419-021-04082-z
PMCID: PMC8445987

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