Article
A Bayesian model selection approach to mediation analysis.
PLoS genetics - 1 May 2022
Crouse Wesley L, Keele Gregory R, Gastonguay Madeleine S, Churchill Gary A, Valdar William
Abstract excerpt
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate for the genetic effects on the other. Alternatively, the phenotypes may be causally unrelated but share genetic loci. Mediation analysis represents a class of causal...
Topics
- Animals
- Bayes Theorem
- Causality
- Mediation Analysis
- Mendelian Randomization Analysis
- Mice
- Phenotype