Article

Engineered bacterial M1GS ribozyme efficiently cleaves the most abundant ribosomal RNA in a human cancer cell line

2025-11-10

Abstract excerpt

M1GS, an engineered Ribonuclease P (RNase P), can be customized to specifically target and cleave any RNA. It involves tethering an Escherichia coli M1 RNA to a short guide sequence (GS) complementary to the RNA targeted for cleavage. We have developed a Python script-based bioinformatic tool built based on the requirements of M1GS, coupled to secondary structure predictions, to identify M1GS target sites for any...

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Literature Corpus work: e8f9e9d1-478a-5763-8683-8840cb622a3c
DOI: 10.1101/2025.11.07.687305

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