Article

Identification of Two Elusive Human Ribonuclease MRP-Specific Protein Components

2025-01-22

Abstract excerpt

<h4>SUMMARY</h4> All known protein components of one of the longest-studied human ribonucleoprotein ribozyme nuclear Ribonuclease MRP (RNase MRP), which processes pre-rRNA at ITS1 site 2, are shared with Ribonuclease P (RNase P), which cleaves pre-tRNA 5′ leader sequences. Our genome-wide forward genetic screening identified two poorly characterized human genes, which we named RPP24 and RPP64. We show that these...

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Literature Corpus work: d90e71f7-d25c-5b11-91dc-b6aa51bf7f34
DOI: 10.1101/2025.01.19.633795

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