Targeted Degradation of Structured RNAs via Ribonuclease-Targeting Chimeras (RiboTacs)

Abstract excerpt

Introduction RNA structural motifs can serve as recognition sites for proteins or regulatory elements. Notably, these specific RNA shapes are directly related to many diseases. Targeting specific RNA motifs using small molecules is an emerging domain of study within the area of drug discovery. Targeted degradation strategies are a relatively modern technology in drug discovery, offering important clinical and...

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