Article

Haplotype-aware modeling of <i>cis</i> -regulatory effects highlights the gaps remaining in eQTL data

2022-01-28

Abstract excerpt

Expression Quantitative Trait Loci (eQTLs) are critical to understanding the mechanisms underlying disease-associated genomic loci. Nearly all protein-coding genes in the human genome have been associated with one or more eQTLs. Here we introduce a multi-variant generalization of allelic Fold Change (aFC), aFC-n, to enable accurate quantification of the cis -regulatory effects in genes with multiple conditionally...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8e4a4fe-979b-5a91-b7e0-82cd2b19de66
DOI: 10.1101/2022.01.28.478116

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Haplotype-aware modeling of <i>cis</i> -regulatory effects highlights the gaps remaining in eQTL dataDOI 10.1101/2022.01.28.478116Read

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data.Semantic proximity Read

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL dataSemantic proximity Read

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read

A vast resource of allelic expression data spanning human tissues.Semantic proximity Read

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read

A vast resource of allelic expression data spanning human tissuesSemantic proximity Read

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networksSemantic proximity Read

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneitySemantic proximity Read

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.Semantic proximity Read

A sequence-based global map of regulatory activity for deciphering human geneticsSemantic proximity Read

Transcription factor regulation of eQTL activity across individuals and tissuesSemantic proximity Read

Predicting genotype-specific gene regulatory networks.Semantic proximity Read