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Article

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.

Genome research - 1 Nov 2017

Mohammadi Pejman, Castel Stephane E, Brown Andrew A, Lappalainen Tuuli

Abstract excerpt

Mapping cis-acting expression quantitative trait loci (cis-eQTL) has become a popular approach for characterizing proximal genetic regulatory variants. In this paper, we describe and characterize log allelic fold change (aFC), the magnitude of expression change associated with a given genetic variant, as a biologically interpretable unit for quantifying the effect size of cis-eQTLs and a mathematically convenient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29021289
DOI: 10.1101/gr.216747.116
PMCID: PMC5668944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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