Article

Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcome

2025-03-25

Abstract excerpt

Tumour development and progression reshape the physical properties of the surrounding tumour microenvironment (TME) including its biomechanical traits. This is driven by a prominent cell type in the TME, cancer associated fibroblasts (CAFs), which increases tissue stiffness via extracellular matrix deposition and remodelling. Currently, it is unclear whether there are also physical changes to CAFs at the cellular...

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Literature Corpus work: e8e42207-294d-55b0-8860-f4e90d7e6d93
DOI: 10.1101/2025.03.21.644569

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