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Article

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer.

Biomaterials - 1 Jul 2013

Clark Ashlee K, Taubenberger Anna V, Taylor Renea A, Niranjan Birunthi, Chea Zhen Y, Zotenko Elena, Sieh Shirly, Pedersen John S, Norden Sam, Frydenberg Mark, Grummet Jeremy P, Pook David W, Stirzaker Clare, Clark Susan J, Lawrence Mitchell G, Ellem Stuart J, Hutmacher Dietmar W, Risbridger Gail P

Abstract excerpt

Stromal-epithelial cell interactions play an important role in cancer and the tumor stroma is regarded as a therapeutic target. In vivo xenografting is commonly used to study cellular interactions not mimicked or quantified in conventional 2D culture systems. To interrogate the effects of tumor stroma (cancer-associated fibroblasts or CAFs) on epithelia, we created a bioengineered microenvironment using human...

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Identifiers

PMID: 23562048
DOI: 10.1016/j.biomaterials.2013.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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