Article

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche

2023-08-29

Abstract excerpt

Analysis of clinical datasets indicate that cancer stem-like cells/tumor-initiating cells (CSCs/TICs) derived from prostate cancer (PCa) patients display an elevated expression of genes for cell-matrix interactions, cell adhesion proteins and of the putative mechanotransducer TAZ. Here we combined measurements on the cellular mechano-responses to matrix stiffness, including cell-generated forces, zebrafish and PDX...

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Literature Corpus work: e1c06749-9832-5f3b-a4af-d0b847c14a0a
DOI: 10.1101/2023.08.28.553410

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