Article

Protracted fate acquisition and epigenetic de-aging during induced neural stem cell conversion of human blood cells

2025-10-26

Abstract excerpt

Transcription factor-based direct conversion of somatic cells represents an interesting avenue for generating induced neural stem cells (iNSCs) from peripheral blood without transit through a pluripotent stage. While this paradigm has been shown to be associated with epigenetic de-aging, the dynamics of this process have remained unclear. Here, we used overexpression of the two reprogramming factors SOX2 and cMYC...

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Literature Corpus work: e8d85c3f-2ab3-5e36-9acb-2e6e02493fa4
DOI: 10.1101/2025.10.25.683217

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