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Article

Fast and efficient neural conversion of human hematopoietic cells.

Stem cell reports - 9 Dec 2014

Castaño Julio, Menendez Pablo, Bruzos-Cidon Cristina, Straccia Marco, Sousa Amaia, Zabaleta Lorea, Vazquez Nerea, Zubiarrain Amaia, Sonntag Kai-Christian, Ugedo Luisa, Carvajal-Vergara Xonia, Canals Josep Maria, Torrecilla Maria, Sanchez-Pernaute Rosario, Giorgetti Alessandra

Abstract excerpt

Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient. We report a fast and efficient approach for generating induced neural cells (iNCs) directly from human hematopoietic cells using Sendai virus. Upon SOX2 and c-MYC...

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Identifiers

PMID: 25458894
DOI: 10.1016/j.stemcr.2014.10.008
PMCID: PMC4264063

Genes

MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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