Article

Sustained epigenetic rejuvenation of serially engrafting human iPSC-derived HSCs

2026-07-17

Abstract excerpt

Hematopoietic stem cell (HSC) function declines with age, contributing to immunosenescence and inferior transplantation outcomes. Here, we generated iPSC-derived HSCs (iHSCs) from multiple adult donors and performed integrated epigenetic, transcriptional, telomeric, and functional analyses to see if they retain youthful identity across differentiation and serial transplantation. Longitudinal DNA methylation profil...

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Literature Corpus work: d5bb5411-e273-5521-8a40-6e4972e61fcd
DOI: 10.64898/2026.07.15.732710

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