Article

wavess 1.2: Presenting an HLA-aware within-host virus sequence simulation framework

2026-02-20

Abstract excerpt

<h4>Motivation</h4> Understanding how virus sequences are shaped by selection can inform vaccine design and transmission inference. Modeling within-host evolution to interrogate these questions requires a detailed mechanistic framework that accurately captures sequence diversification. The CD8 + cytotoxic T-lymphocyte (CTL) response plays an important role in immune-mediated selection and can leave strong signat...

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Literature Corpus work: e8d53b38-0bd7-5ae6-98cc-f138821162a6
DOI: 10.64898/2026.02.19.706869

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