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Article

Epitope discovery with phylogenetic hidden Markov models.

Molecular biology and evolution - 1 May 2010

Lacerda Miguel, Scheffler Konrad, Seoighe Cathal

Abstract excerpt

Existing methods for the prediction of immunologically active T-cell epitopes are based on the amino acid sequence or structure of pathogen proteins. Additional information regarding the locations of epitopes may be acquired by considering the evolution of viruses in hosts with different immune backgrounds. In particular, immune-dependent evolutionary patterns at sites within or near T-cell epitopes can be used...

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Identifiers

PMID: 20089717
DOI: 10.1093/molbev/msq008
PMCID: PMC2857806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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