Article
Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations.
Nature communications - 21 Mar 2024
Lou Jingzhi, Liang Weiwen, Cao Lirong, Hu Inchi, Zhao Shi, Chen Zigui, Chan Renee Wan Yi, Cheung Peter Pak Hang, Zheng Hong, Liu Caiqi, Li Qi, Chong Marc Ka Chun, Zhang Yexian, Yeoh Eng-Kiong, Chan Paul Kay-Sheung, Zee Benny Chung Ying, Mok Chris Ka Pun, Wang Maggie Haitian
Abstract excerpt
Influenza virus continuously evolves to escape human adaptive immunity and generates seasonal epidemics. Therefore, influenza vaccine strains need to be updated annually for the upcoming flu season to ensure vaccine effectiveness. We develop a computational approach, beth-1, to forecast virus evolution and select representative virus for influenza vaccine. The method involves modelling site-wise mutation fitness....
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