Article

Quantitative comparison of PI(3,5)P <sub>2</sub> biosensors reveals SnxA is the most sensitive and unbiased

2025-11-11

Abstract excerpt

PI(3,5)P 2 is an endosomal lipid whose depletion is associated with a variety of pathologies such as neurodegenerative diseases. However, studying this lipid in physiological and disease models has been difficult due to the scarcity of the lipid and the lack of live-cell imaging tools. That is until recently, when a novel PI(3,5)P 2 biosensor, SnxA, was characterized. Despite the exciting promise of this new sen...

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Literature Corpus work: e8b5f1c1-f7db-5f2a-9d59-da2703d33946
DOI: 10.1101/2025.11.10.687688

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