Article
Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics.
Molecular bioSystems - 1 Sept 2010
McCombs Janet E, Gibson Emily A, Palmer Amy E
Abstract excerpt
The ER plays a fundamental role in storing cellular Ca(2+), generating Ca(2+) signals, and modulating Ca(2+) in both the cytosol and mitochondria. Genetically encoded Ca(2+) sensors can be explicitly targeted to the ER to directly define Ca(2+) levels and monitor fluxes of Ca(2+) within this organelle. In this study we use an ER-targeted Ca(2+) sensor to define both the level and dynamics of ER Ca(2+) in cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.