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Article

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2011

Zampese Enrico, Fasolato Cristina, Kipanyula Maulilio J, Bortolozzi Mario, Pozzan Tullio, Pizzo Paola

Abstract excerpt

Presenilin mutations are the main cause of familial Alzheimer's disease (FAD). Presenilins also play a key role in Ca(2+) homeostasis, and their FAD-linked mutants affect cellular Ca(2+) handling in several ways. We previously have demonstrated that FAD-linked presenilin 2 (PS2) mutants decrease the Ca(2+) content of the endoplasmic reticulum (ER) by inhibiting sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA)...

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Identifiers

PMID: 21285369
DOI: 10.1073/pnas.1100735108
PMCID: PMC3041131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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