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Article

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jan 2014

McCartney Amber J, Zhang Yanling, Weisman Lois S

Abstract excerpt

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol, PI(3,5)P2 is dynamically generated on multiple cellular compartments where interactions...

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Identifiers

PMID: 24323921
DOI: 10.1002/bies.201300012
PMCID: PMC3906640

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