Article

PIKfyve is an essential component of the endolysosomal pathway within photoreceptors and the retinal pigment epithelium

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Phosphoinositides (PIs) are a family of seven low abundance membrane lipids, each with distinct signaling functions. The phosphoinositide kinase PIKfyve generates phosphoinositide-3,5-bisphosphate (PI(3,5)P₂) and PI5P. Emerging evidence implicates PIKfyve in key cellular processes, including autophagy, phagocytosis, endosomal trafficking, lysosomal maintenance, and melanosome formation. Complete...

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Literature Corpus work: e4de3e39-7735-5d07-9b85-f2bf6fc5b46a
DOI: 10.1101/2025.09.15.676399

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