Article

Dual effect of α-synuclein disease variants on condensate formation

2025-06-10

Abstract excerpt

<h4>SUMMARY</h4> α-synuclein is a pre-synaptic protein 1,2 implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites 3 . Recent studies have reported that α-synuclein undergoes phase separation to form biomolecular condensates both in vitro and in mammalian cells 4–7 . α-synuclein condensates ar...

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Literature Corpus work: a395c9bb-9bf8-58b3-b7e8-a7e21ee58014
DOI: 10.1101/2025.06.06.657340

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