Article

The oncogenic Runx3–Myc axis defines <i>p53</i> -deficient osteosarcomagenesis

2021-05-03

Abstract excerpt

Osteosarcoma (OS) in human patients is characterized by genetic alteration of TP53 . Osteoprogenitor-specific p53 -deleted mice ( OS mice) have been widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms responsible for the development of OS upon p53 inactivation remain largely unknown. In this study, we detected prominent RUNX3/Runx3 expression in human and mouse p53 -defic...

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Literature Corpus work: e88d1411-9e38-568b-b3c8-717fd02e03d6
DOI: 10.1101/2021.05.03.442316

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