WWOX promotes osteosarcoma development via upregulation of Myc

Abstract excerpt

Osteosarcoma is an aggressive bone tumor that primarily affects children and adolescents. This malignancy is highly aggressive, associated with poor clinical outcomes, and primarily metastasizes to the lungs. Due to its rarity and biological heterogeneity, limited studies on its molecular basis exist, hindering the development of effective therapies. The WW domain-containing oxidoreductase (WWOX) is frequently alt...

Topics

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• Inheritance Patterns
• Genetics and Neurodevelopmental Disorders
• Genomics
• High-Throughput Nucleotide Sequencing
• Mutation
• Osteosarcoma
• Peptidase Inhibition and Analysis
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

ed522c69-5117-52d3-8ce0-93acce1ca569

DOI

10.1101/2023.03.14.532523