Article

<i>miRNA-34c</i> suppresses osteosarcoma progression <i>in vivo</i> by targeting Notch and E2F

2021-05-25

Abstract excerpt

<h4>ABSTRACT</h4> The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, miR-34c , an effector of tumor suppressor P53 and an upstream negative regulator of Notch signaling in osteoblast differentiation, is dysregulated in OS. Here, we demonstrated a tumor suppressive role of miR-34c in OS progression usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27add410-af95-5135-824e-e0c248968110
DOI: 10.1101/2021.05.24.445452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>miRNA-34c</i> suppresses osteosarcoma progression <i>in vivo</i> by targeting Notch and E2FDOI 10.1101/2021.05.24.445452Read

MicroRNA-744-5p Suppresses Tumorigenesis and Metastasis of Osteosarcoma Through the MAPK/ERK Signaling Pathway by Targeting TGFB1Semantic proximity Read

MicroRNA-342-3p Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting Astrocyte-Elevated Gene-1 (AEG-1)Semantic proximity Read

Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcomaSemantic proximity Read

miRNA-331-3p Affects The Proliferation, Metastasis And Invasion of Osteosarcoma Through SOCS1/JAK2/STAT3Semantic proximity Read

MicroRNA-27a Promotes Proliferation, Migration and Invasion by Targeting<b><i>MAP2K4</i></b>in Human Osteosarcoma CellsSemantic proximity Read

Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma.Semantic proximity Read

miR-766-3p suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis by targeting BCL9L via β -catenin signaling pathway in osteosarcoma cellsSemantic proximity Read

Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcomaSemantic proximity Read

LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.Semantic proximity Read

Prognostic value of microRNAs in osteosarcoma: A meta-analysis.Semantic proximity Read

RUNX2 and OsteosarcomaSemantic proximity Read

Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B.Semantic proximity Read