Article

C/ebpα represses the oncogenic Runx3–Myc axis in p53-deficient osteosarcoma development

2022-10-11

Abstract excerpt

<title>Abstract</title> <p>Osteosarcoma (OS) is characterized by <italic>TP53</italic> mutations in humans. In mice, loss of p53 triggers OS development, and osteoprogenitor-specific <italic>p53</italic>-deleted mice are widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms underlying the initiation or progression of OS following or parallel to p53 inactivation remain largely...

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Literature Corpus work: 93db5fee-4c9a-57c7-899b-6aa5c6531a26
DOI: 10.21203/rs.3.rs-2103215/v1

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