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Article

Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination.

Cancer research - 15 Oct 2009

Chi Xin-Zi, Kim Jiyeon, Lee Yong-Hee, Lee Jung-Won, Lee Kyeong-Sook, Wee Heejun, Kim Wun-Jae, Park Woo-Yoon, Oh Byung-Chul, Stein Gary S, Ito Yoshiaki, van Wijnen Andre J, Bae Suk-Chul

Abstract excerpt

The p14(ARF)-MDM2-p53 pathway constitutes an effective mechanism for protecting cells from oncogenic stimuli such as activated Ras and Myc. Importantly, Ras activation induces p14(ARF) and often occurs earlier than p53 inactivation during cancer development. Here, we show that RUNX3, a tumor supp...

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Share to Core Binding Factor Alpha 3 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-mdm2

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Share to Tumor Suppressor Protein p14ARF

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Source

Open in PubMed Open full text

Identifiers

PMID: 19808967
DOI: 10.1158/0008-5472.CAN-09-1057
PMCID: PMC3059505

Genes

MDM2
RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19808967-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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