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Article

Modifying T cell phenotypes using TYK2 inhibitor and its implications for the treatment of systemic lupus erythematosus.

RMD open - 13 Jun 2024

Satoh-Kanda Yurie, Nakayamada Shingo, Kubo Satoshi, Yamagata Kaoru, Nawata Aya, Tanaka Hiroaki, Kosaka Shunpei, Kanda Ryuichiro, Yu Shan, Fujita Yuya, Sonomoto Koshiro, Tanaka Yoshiya

Abstract excerpt

OBJECTIVES: The tuning effects of JAK/TYK2 inhibitors on the imbalance between T follicular helper (Tfh) and T regulatory (Treg) cells, related to systemic lupus erythematosus (SLE) pathogenesis, were investigated using human peripheral blood samples. METHODS: Peripheral blood mononuclear cells from untreated patients with SLE and healthy controls were analysed. Tfh1 cells were identified in nephritis tissue, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38871479
DOI: 10.1136/rmdopen-2023-003991
PMCID: PMC11177773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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