Article

Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility

2025-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Genetic studies have linked EPHX2 (encoding soluble epoxide hydrolase, sEH) and PTGS2 (encoding cyclooxygenase-2, COX-2) to Alzheimer’s disease (AD). Elevated levels of sEH and COX-2 found in AD patients and animals suggest their involvement in neurodegeneration, glial activation, vascular dysfunction, and inflammation. This study evaluated the effects of a new dual sEH/COX-2 inhibitor, PTUPB,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b106d0f0-3558-57e1-8fe1-b1b5e6760542
DOI: 10.1101/2025.08.21.669945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery DistensibilityDOI 10.1101/2025.08.21.669945Read

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat ModelsSemantic proximity Read

Inhibition of Soluble Epoxide Hydrolase Rescues Cognitive Deficits by Preserving Neurovascular Integrity and Attenuating Glial- and Neuropathology in Diabetic-Related DementiaSemantic proximity Read

Soluble epoxide hydrolase in Alzheimer’s disease drives neurovascular dysfunctionSemantic proximity Read

Role of soluble epoxide hydrolase in age-related vascular cognitive decline.Semantic proximity Read

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunctionSemantic proximity Read

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkSemantic proximity Read

Sex-specific mechanisms of cerebral microvascular BK <sub>Ca</sub> dysfunction in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s diseaseSemantic proximity Read

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer’s disease: therapeutic potential of timapiprant a DP2 antagonistSemantic proximity Read

Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer diseaseSemantic proximity Read

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profilingSemantic proximity Read

Medin Induces Pro-Inflammatory Activation of Human Brain Vascular Smooth Muscle CellsSemantic proximity Read