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Article

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.

Experimental and molecular pathology - 1 Apr 2013

Cimino Patrick J, Yang Yue, Li Xianwu, Hemingway Jake F, Cherne Makenzie K, Khademi Shawn B, Fukui Yoshinori, Montine Kathleen S, Montine Thomas J, Keene C Dirk

Abstract excerpt

Alzheimer's disease (AD) neuropathology is characterized by innate immune activation primarily through prostaglandin E2 (PGE2) signaling. Dedicator of cytokinesis 2 (DOCK2) is a guanyl nucleotide exchange factor expressed exclusively in microglia in the brain and is regulated by PGE2 receptor EP2. DOCK2 modulates microglia cytokine secretion, phagocytosis, and paracrine neurotoxicity. EP2 ablation in experimental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23318649
DOI: 10.1016/j.yexmp.2013.01.002
PMCID: PMC3602334

Genes

DOCK2

Provenance

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