Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.

Neurobiology of aging - 1 Apr 2012

Amtul Zareen, Uhrig Markus, Wang Lin, Rozmahel Richard F, Beyreuther Konrad

Abstract excerpt

Inflammation is believed to be integral to the pathogenesis of Alzheimer's disease (AD). Arachidonic acid (AA) is the most important omega-6 fatty acid and a mediator of inflammatory pathways. High-sensitivity enzyme linked immunosorbent assay shows that AA and its various metabolites; prostaglandins, thromboxanes, and leukotriene B4 resulted in significantly higher secretion of both Abeta40 and 42 peptides. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Arachidonic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biosynthetic Pathways

Share to Biotinylation

Share to Dietary Supplements

Share to Immunoprecipitation

Share to Plaque, Amyloid

Share to Prostaglandins

Source

Identifiers

PMID: 21920632
DOI: 10.1016/j.neurobiolaging.2011.07.014

Genes

PGF
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.PMID 21920632Read ↗

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.Semantic proximity Read ↗

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.Semantic proximity Read ↗

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimerâ€™s disease phenotypeSemantic proximity Read ↗

7-ketocholesterol enhances BACE1-amyloid precursor protein cleavage and amyloidogenic peptide generation targeted by natural moleculesSemantic proximity Read ↗

Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease.Semantic proximity Read ↗

Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation ControlSemantic proximity Read ↗

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.Semantic proximity Read ↗

αS oligomers generated from polyunsaturated fatty acid and dopamine metabolite differentially interact with Aβ to enhance neurotoxicitySemantic proximity Read ↗

Beyond Symptom Management: FAAH Inhibition as a Path to Mitigate Alzheimer’s Disease Progression in Mouse Models of AmyloidosisSemantic proximity Read ↗

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila and cellular models of Alzheimer's diseaseSemantic proximity Read ↗

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer’s disease: therapeutic potential of timapiprant a DP2 antagonistSemantic proximity Read ↗

Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.