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Article

Cyclooxygenase-2 gene polymorphisms and risk of Alzheimer's disease: A meta-analysis.

Journal of the neurological sciences - 15 Dec 2015

Luo Dong, Long Yan, Chen Guo-Jun

Abstract excerpt

PURPOSE: Cyclooxygenase-2 (COX-2) is one of the key enzymes in the synthesis of prostaglandins, and plays a pivotal role in inflammatory response. Recent studies have suggested cyclooxygenase-2 is involved in the pathogenesis of Alzheimer's disease (AD). However, the relationship between COX-2 gene polymorphisms (-765G>C rs20417, -1195A>G rs689466) and Alzheimer's disease risk is not conclusive. We conducted a...

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PMID: 26671095
DOI: 10.1016/j.jns.2015.10.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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