Article

Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis

2022-01-22

Abstract excerpt

Cancer occurs as a consequence of multiple somatic mutations that lead to uncontrolled cell growth. Mutual exclusivity and co-occurrence of mutations imply—but do not prove—that they can exert synergistic or antagonistic epistatic effects on oncogenesis. Knowledge of these interactions, and the consequent trajectories of mutation and selection that lead to cancer has been a longstanding goal within the cancer rese...

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Literature Corpus work: e8660ef8-067f-539d-baf7-83ea0fdb6038
DOI: 10.1101/2022.01.20.477132

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